Tandac Furkan Guclu

Assistant Professor at Istinye University

Resume

Tandac Furkan Guclu

İstinye University – Vocational School of Health Care Services
Topkapı Campus, Maltepe Mah., Edirne Çırpıcı Yolu No.9, 34010 Zeytinburnu, Istanbul, Turkey tandac.guclu@istinye.edu.tr
CV, ORCID, Google Scholar

Education

  • PhD, Molecular Biology, Genetics and Bioengineering
    Sabanci University, Istanbul, Turkey (2015 – 2021)
    Thesis: Molecular Level Understanding of the Functionality of PDZ3 Variants via Advanced All-Atom Simulations and Dynamic Residue Network Analyses
    Advisors: Dr. Canan Atilgan, Dr. Ali Rana Atilgan

  • MSc, Bioengineering
    Marmara University, Istanbul, Turkey (2013 – 2015)
    Thesis: Structural Dynamics of von Hippel-Lindau Tumor Suppressor Protein
    Advisor: Dr. Asuman Nevra Ozer

  • BSc, Biology
    Hacettepe University, Faculty of Science, Istanbul, Turkey (2007 – 2013)

Work Experience

  • Assistant Professor, İstinye University, Istanbul, Turkey (2025 – present)

  • Postdoctoral Researcher, Sabanci University, Istanbul, Turkey (2021 – 2025)
    • Researcher at EuroCC4SEE (2024 – 2025)
    • Researcher at EuroCC2 project (2023 – 2024)
    • Researcher at EuroCC project (2022 – 2023)
    • Online open lectures:
      • Molecular Dynamics Simulations of Small Molecules
      • Prediction of Protein Structures Using Deep Learning Tools
      • Generating Mutant Protein Structures Using Advanced Techniques
      • Residue Networks: Understanding the Time Evolution and Mutations of Proteins from a Graph Theoretical Perspective
    • Co-lecturer of Computational Techniques for Materials at the Nano-scale (MAT 306), two semesters
    • Undergraduate projects (Program for Undergraduate Research (PURE)):
      • Visual Assessment of AlphaFold2-Predicted Possible Transcytosis Protein Structures (with Dr. Nur Mustafaoğlu)
      • DeepMind vs. Academia: How good are the best AI models in discriminating similar sequences of a given protein? (with Dr. Canan Atilgan)
    • Graduation project (ENS491 – ENS492):
      • Temporal hydrogen-bond networks in proteins (with Dr. Ali Rana Atilgan)
  • Lecturer for School of Molecular and Theoretical Biology, Sabanci University, Turkey (July – August 2024)
    • Organized at Sabanci University
    • Delivered a six-week-long course titled “Exploring GB1 Protein Dynamics: A Graph Theoretical Perspective” for high school and undergraduate students from various countries
  • Lecturer, Kadir Has University, Istanbul, Turkey (Spring 2024)
    • Molecular Biology and Genetics, project-based education
    • Protein Modeling and Simulation, project-based education
  • Short-term Visiting Scholar, Pennsylvania State University, University Park, PA, USA (January 2024)
    • Collaboration with Dr. Melik C. Demirel
    • Predicting the materials properties of tandem repeat proteins
  • Short-term Visiting Scholar, University of Texas Southwestern, Dallas, TX, USA (February 2023)
    • Collaboration with Dr. Erdal Toprak
    • Drug design and bioinformatics analyses of bacteria drug resistance pathways
  • Virtual Workshop in the MIDST of Centrality and Community Detection in Dynamic Residue Networks (March 2021)
    • Full-day online workshop as part of global Biophysical Week
  • Teaching Assistant (Virtual), University of Texas Southwestern Medical Center, Dallas, Texas, USA (February 2021)
    • Micro course: Protein Structures as Residue Networks (PSARN), five weeks
  • Teaching Assistant, Sabanci University, Istanbul, Turkey (2015 – 2021)
    • Science of Nature (NS 101), seven semesters
    • Introduction to Bioinformatics (BIO 310), two semesters
    • Computational Biology (ENS 210), one semester
    • Computational Approaches to Problem Solving (IF 100), one semester
    • Fundamentals of Nanoscience (NS 218), one semester
    • Computational Techniques for Materials at the Nano-scale (MAT 306), one semester
    • Graduation Project (ENS491 – 492), co-supervisor with Dr. Canan Atilgan
      • Carving Lattices to Construct Protein-Like Structures
  • Short-term Visiting Researcher, Rhodes University, Grahamstown, South Africa (August 2017)
    • Collaboration with Dr. Özlem Taştan Bishop
    • Scanning resistance conferring mutants of DHFR to specify drugs optimizing inhibition

Papers

  • Guclu T.F., Tayhan B., Cetin E., Atilgan A.R., Atilgan C., High Throughput Mutational Scanning of a Protein via Alchemistry on a High-Performance Computing Resource. Concurrency and Computation: Practice and Experience, 2025, 37, e8371. https://doi.org/10.1002/cpe.8371 – Research Article (Published). (Corresponding Author)

  • Guclu T.F., Atilgan A.R., Atilgan C., Deciphering GB1’s Single Mutational Landscape: Insights from MuMi Analysis. The Journal of Physical Chemistry B, 2024, 128 (33), 7987–7996. https://doi.org/10.1021/acs.jpcb.4c04916 – Research Article (Published). (Corresponding Author)

  • Kantarcioglu I., Gaszek I.K., Guclu T.F., Yildiz M.S., Atilgan A.R., Toprak E., Atilgan C., Structural shifts in TolC facilitate Efflux-Mediated β-lactam resistance. Communications Biology, 2024, 7, 1051. https://doi.org/10.1038/s42003-024-06750-0 – Research Article (Published).

  • Cetin E., Guclu T.F., Kantarcioglu I., Gaszek I.K., Toprak E., Atilgan A.R., Dedeoglu B., Atilgan C., Kinetic Barrier to Enzyme Inhibition Is Manipulated by Dynamical Local Interactions in E. coli DHFR. Journal of Chemical Information and Modeling, 2023, 63 (15), 4839–4849. https://doi.org/10.1021/acs.jcim.3c00818 – Research Article (Published).

  • Guclu T.F., Atilgan A.R., Atilgan C., Dynamic Community Composition Unravels Allosteric Communication in PDZ3. The Journal of Physical Chemistry B, 2021, 125 (9), 2266–2276. https://doi.org/10.1021/acs.jpcb.0c11604 – Research Article (Published).

  • Guclu T.F., Kocatug N., Atilgan A.R., Atilgan C., N-Terminus of the Third PDZ Domain of PSD-95 Orchestrates Allosteric Communication for Selective Ligand Binding. Journal of Chemical Information and Modeling, 2021, 61 (1), 347–357. https://doi.org/10.1021/acs.jcim.0c01079 – Research Article (Published).